Act 4: Forbidden Zone
The Only Way ThroughKick down the first sign to form a bridge. The area is filled with fruit that can blind and stun the enemies by kicking the vegetation in their face. Since the foes are still too fast for your Leash, use your carbine rifle to take out the Kreeps with ease. After the fight, crouch through the path Trishka finds and kill off the robot. Leash the fan on the left to move to the next area.
The plants in the area will slurp up and eat up a lone Kreep, resulting in a critical event to gain some extra skillpoints. Kick down the next door and grab the cable to slide across the chasm. Here, there will be legions of Kreep snipers coming up next so use your own Head Hunter sniper rifle to deal with them.
After another cutscene, you come to an area blocked by a barrier of cars. Trishka will ask you to solve this problem in a few seconds. Take down the globe behind you to clear a path. If you stall, Trishka will do it for you. Beyond the barrier enter the tent on the left to get another robot. As you're attacked by Skulls use the cacti to gain some Pricked points. Next, a new Bouncer boss will appear. Shoot its backpack to blow off the boss's armor; he will now be vulnerable to his body and helm shots just like the minigun boss.
Maneaters Prefer Tight Spots
This stage introduces psychotropic spores that will blur vision. They can however be used against the enemies to confuse them as well. The wild plant life will pull Ishi down a hole, leaving just you and Trishka for this chapter.
Use the cacti and maneater plants to take down the Skull hordes. If you get caught on a maneater, escape quickly as it can mean instant death. There are also a lot of Flailgun collar enemies that can be used to score Bombshell points.
Destroy the robot ahead and take down the Banshee cruiser and Vultures the Skull summon. A mingun boss will appear, so take him down and grab his gun to easily massacre the rest of the Skulls. Use the maneaters to kill off the remaining enemies, but be sure not to get attacked by the plants yourself.
Stock up on ammo as you will need a huge supply to take down the next boss. Use your charges and normal carbine shots to take down its first meter. Afterwards, it will attempt to regenerate, so stop it by shooting down the glowing balls on its body. After all of the orbs are cleared off, it will enter a new form. Avoid the spores and mash the button to move out of the way of it's mouth. Take out the tentacles that emerge to keep it from regenerating again. Use your charges from the carbine, Flailgun and Bouncer.
Itchin to Crumble
You'll meet up with Ishi again at the start of the chapter. Travel with your two allies who will show the path through the crushed building. Use your leash to Voodoo the Skulls and take the mounted machine gun to mow down more the enemies from a far. Call down the elevator and head up to the next area. There will be another robot to mutilate, but otherwise continue to the next area.
There are lots of Skulls here, but also lots of terrain hazards to score Vertigo and Voodoo points. Run ahead and cross the window floor quickly, as it will crack under your weight. Stop to grab a beer on the ground and keep going. Take down the minigun boss and use Voodoo to score loads of points. Soon, the building will crumble and you'll need to run like mad. Ignore the enemies and just keep going to finish the Act.