Proving Grounds

A semi-tough little area here. With the Little Sister at your side, you'll need to escort her through two separate corridors, while attempting to prevent the numerous Splicers in the area from killing her. The girl will run at her own pace while you're nearby; if you move far away from her, she'll stop, but she'll also be undefended.

Tip: If a Little Sister gets killed here, you can summon another one by banging on a wall vent with your wrench. There's no achievement for not getting a Sister killed, so don't worry too much if you lose a couple.

Luckily, your appearance as a Big Daddy will prevent the security systems from locking onto you; however, if you've been rescuing the Little Sisters, then your ward will be foreign to the security, so you'll need to hack everything you see. You should hack away anyway, since the Little Sister will periodically stop at a corpse and extract ADAM from it. This will be the most difficult part of the escort, since numerous Splicers will start coming at you during these trials. Most of the corpses will have a turret or a camera somewhere nearby, so be sure to hack those and enlist them to help you defend the little girl. Also try to set traps for the incoming enemies by laying down proximity mines, Cyclone Traps, and setting the nearby oil fields ablaze.

Escortion

The first two rest stops are a bit more complicated than the last one, so try to save your more powerful ammo, like proximity mines, for the second half of the trip. After you pass through the room where the dinosaur bones have fallen from the ceiling, you'll come to a pool of water where many Splicers are waiting for you. Frag grenade them out of sight, then head around the corner and quickly hack the turret and camera near the last body. This is going to be the hardest test for you to keep the girl alive. The turret and camera will be able to keep most of the enemies from further down the hallways at bay, so concentrate on nagging the enemies that come from the direction you've already travelled. Hitting them with napalm seems to help incapacitate them while also dealing damage.

Guard the Sisters closely while they harvest their Adam, or they'll quickly go down..

Lastly, a Bouncer will pop out of a wall while you turn the corner to the last door you need to get through. Quickly hit it with frag grenades or powered-up crossbow bolts to take it down, then get to the final staging area before the boss fight.

When you have the Little Sister's needle in hand, make as much ammo as you can at the U-Invent machine here and get ready for a fight by buying first aid kits. (Don't spend all your cash, though; try to save at least 50 bucks.) Static Field 2 might be a handy tonic to have for the upcoming fight.

Fontaine

The end boss guy attacks you here as soon as the level begins. You have to fight him in three forms in order to finally kill him. Start the fight by running up to him while he's strapped to the chair and using the needle to drain his ADAM; that'll cause him to react…violently. You can't hit a Vita-Chamber here, so you have to finish him off in one life.

His power level is over 9000!!!!!

There are three phases here: one where Fontaine attacks you in a fire form, one where he's ice, and one where he's electrical. Each is pretty similar in functionality, however; they each have a powerful ranged attack and a very quick-moving charge attack. Kind of like a combination of a Bouncer and a Rosie, in effect. One thing is constant, and that's the fact that Fontaine is very resistant to damage: it'll take a long time to take him down, no matter what phases he's in. Note the appearance of a first aid station in one corner of the area. Instead of using first aid kits, you might want to try hacking that and using it when you run low on health.

Video Walk-through

Fontaine won't go down without a fight, but if you know what you're doing, you can take him out.

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Anyway, dealing with Fontaine isn't too difficult, at least not on the Medium difficulty. The first form here is going to be fire-based, with a huge fireball that he can send your way. Stay in the middle of the area and strafe to avoid his charge attack. He'll basically just charge at you, turn around, fling a fireball, charge again, and so on. Each of his attacks can be pretty easily dodged if you just keep moving to the side. Try to paste Fontaine with liquid nitrogen from your chemical thrower until he's good and frozen, then wrench him for a bit. That'll wear down his health a good amount, allowing you to repeat the process and finish him off without too much wear and tear. If you like, you can, of course, use other weapons or plasmids on him, but again, he's pretty resistant to damage.

Wearing Him Down

After you take off one life bar of Fontaine's, he'll reappear in his little medical chair and start the Adam pumping again. Get close to him and needle him again. He'll summon a security bot or two to help him at the beginning of the next phase of the fight, so quickly find the bot shutdown panel near his chair and shut them down before quickly hacking them.

Your chemical thrower will be a great way to wear down Fontaine's first two forms.

Fontaine is icy now, but no matter: his attacks are pretty much identical. Napalm will be a good bet against him here, if you've upgraded your chemical thrower, but anything will work, for the most part. Wear him down until he returns to the chair, then needle him again and prepare for the final assault.

Video Walk-through

SPOILERS: This is but one of a reported three endings to the game.

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In his electrical form, Fontaine isn't too much more difficult to deal with, but he'll summon in an apparently endless amount of splicers to help him out. You might be disoriented by the fire that comes from multiple directions, but you should be able to take it by now, assuming you didn't use up all of your first aid kits. If you have any kind of ammo for your grenade launcher, now would be a good time to use it; you can also try using telekinesis to fire the explosive containers onto his body. We also had decent luck with explosive shells for the shotgun; if he catches on fire, he'll head to the water in the rear of the room. While you can't do much in the way of electrifying the water to hurt him, he'll be a little less mobile while he stays in there, allowing you to pound on him a bit more effectively.

After you wear down his final health bar, stick the needle in Fontaine one last time to end the game. We're told there are three endings: one for rescuing all of the Little Sisters, one for harvesting all of them, and another ending for proceeding with a mixture of both actions. If we get more details on these endings, we'll update this guide with extra info on how they're unlocked.