Dealing with Manuel

There are two primary methods for taking out Manuel, who hangs out in the wine cellar. The first is to construct a convenient equipment malfunction. The western edge of the wine cellar has a stairwell leading up to the courtyard; at the top of this stairwell is a winch that controls a makeshift wine barrel elevator. Luckily for you, Manuel will often either be standing in this area by himself, or attempting to bring down one of his work associates to the small area just beneath this elevator, allowing you to place a bomb on the winch, then detonate it as he lounges around underneath it.

Poisoning Manuel is the quietest way to take him on.

If you want to be sure that the elevator drops as planned, you can hide behind the stacks of barrels nearby and wait for just the right moment before dropping the elevator. This explosion is generally more likely to take Manuel out if he's standing there by himself; if you wait for his friend to come down, they'll stand off to one side and will usually survive the falling wine barrels. If you don't want to stage a huge accident, though, you can just plant the bomb where they wind up standing and blow them up directly.

If you let Manuel and friend leave the area, they'll walk to the east, towards the drug lab, which is hidden behind a large, empty wine barrel. If they make it into the drug factory, then your chances of taking them down quietly dim, so you may want to just let them go, deal with Don Fernando, then come back and attempt to get a better read on Manuel when you've offed his old man. If you do, you can sometimes come back and find him simply standing around by the bottom of the stairs, allowing you to fiberwire him and hide his body with minimal troubles, assuming the wine tour isn't passing through.

Alternately, Manuel will also occasionally test his drug lab's supplies at a table near the stairs. It's somewhat secluded, in a small room with a storage bin, but there'll usually be a guard looking directly at the table, so if you want to take out Manuel here, you'll probably have to eliminate the guard first, or just plant the bomb here, instead of on the winch. Alternately, you can wait until he starts walking towards the small door here and take him down with your poison syringe. If you can manage to take him down quietly, then you can stuff him in the bin nearby and rest assured that no one will discover his body for a while.

Taking On The Don

Don Fernando doesn't move around much, thankfully, preferring to spend most of his time during this mission practicing his cello playing and enjoying the view from his balcony.

Sniping

If you're looking for a distant method of taking him down, then you can use your sniper rifle to take him on. There's a good little sniper roost near the waterfall to the east of the hacienda, but you can also wait near the chair with shotgun and SMG ammo to the west, although this angle will prevent you from seeing much of his upper body. Whichever you prefer to take, you'll have to kill or incapacitate the guard that's on patrol nearby before setting up your rifle; they'll shoot you on sight if they see you carrying it. As mentioned, the Don only appears once every few minutes, so you'll have to scope in on his balcony (the middle of the three balconies in the hacienda), and hope that your scope drift doesn't make it impossible to hit him. At this point, you won't have been able to upgrade your rifle enough to make this a sure bet, but if you have the quietest ammo, missed shots won't generally set off the alarm, allowing you to wait for him to reappear before trying again. Don't forget to crouch and stay still if you want the best accuracy for your shot.

Up Close And Personal

Apart from that, your only option is to enter the mansion itself and take the old man out at close range. You can get more or less free run of the area if you can get a VIP Guard suit, but these are difficult to come by, since most of the guards are densely situated in the hacienda or the drug lab. As mentioned in the Setup section above, your best bet to find one of these is to head down to the seaplane hangar and kill the guards there. If you can grab one, then getting up close and personal to the Don will be much simpler, although you'll still have to pick some locks in the same hallway as VIP guards on patrol, which is a risky business.

Taking out the Don from close range is easiest if you approach from one of the waterpipes.

The best bet for getting to the Don with minimal trouble is to find one of the waterpipes on the side of the house. There's one to the west, which is usually overwatched by a somewhat sleepy guard, but the one on the east side of the house, which is only accessible by passing into the yard of the hacienda (and which will thus require you to be wearing at least a normal guard or worker outfit), leads directly into the Don's private quarters, where he plays cello. No lockpicks required! The main danger here is that the guard patrolling the eastern side of the estate, outside the walls, may see you either climbing the pipe or running around on the roof, neither of which are going to be necessarily neutral activities. If you have full map data, you can time your climbing for when he's facing away from you; otherwise, you'd best just take him out ahead of time.

When you're inside the room, all you need to do is wait for the Don to start playing cello, then sneak up behind him and use your poison, fiberwire, silenced pistol, or whatever else you have to kill him. Don't worry about the sound that the cello's making; breaking off a song midway through won't alert the nearby guards. You also don't have to worry so much about dumping the body, although you can feel free to throw it over the balcony if you wish; it'll land on one of the walkways leading to the seaplane hangar, where no one will ever find it.