Alpha-152
Alpha-152 isn't a playable character in DOA4, but she does show up as the final boss in almost all of the Story Mode and Time Attack games. She is going to be very difficult for most players to defeat even once, let alone two out of three times in a row. (Note that neither people who play every fighting game that hits the market nor 12-year-old Japanese boys count as "most people.")
Of course, if you're an excellent player and can counter in mid-combo with regularity, then with enough practice, you should be able to counter Alpha's combos with relative ease, since she only has a few of them. (Try using mid-punch holds against her punch combos, and low attack holds against kicks.) The bulk of the problems when fighting Alpha are as follows: she can teleport out of your way to almost anywhere on the map, even when you're unloading a combo on her; she has a number of devastating combos, and throws that move much more quickly than do those of any other character (and her throw can also be performed from much farther away with barely a flicker of an animation to precede it); and her most damaging abilities take a long time to play out and can sap the majority of your life in one hit if they come in as a counter or hi counter. So yes, she's pretty much one of the most annoying parts of the game.
Video Walk-through
Defeating Alpha-152 is never an easy matter; sometimes just spamming out combos is the best way to go.
Unfortunately, there's no cut-and-dried method of defeating Alpha-152 consistently. It seems like the quicker characters, like Christie and Ayane, are going to have an easier time defeating her than will slower characters, mostly due to the fact that Alpha doesn't really attempt to hold your moves very often, and when she does, she seems to almost always go for a medium punch hold. Thus, if you mash out a P, P, P, etc. combo, most characters will unload high punches and you can often get her but good, assuming she doesn't teleport out of the way. So, basically, try to button mash if possible. It won't always work, by any means, but if you can aggressively seek her out and try to button mash you can sometimes get good hits in and wear her down.
Alternately, you can try to use one of your running punch or kicks attack to strike from long range. Alpha usually keeps her distance from you, especially after she's unloaded a combo on you. If you feel that the timing's right, try using one of your running moves to cover the distance and slam into her. If you attempt to perform one of these while you're really far away, she'll probably teleport, but if you perform them while standing just outside of range of combo strikes, you can often connect with them. You can also try waiting for her to teleport close to you, then hit back and P+K to perform one of your charge moves that'll knock her away from you. It isn't foolproof, but should hopefully connect often enough to wear her down.
We still find that a host of things have to go precisely right in order to beat Alpha-152, especially if you're trying to beat her with a slower character. Be prepared to try her numerous times in a row before you get lucky and bring her down.
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