Probably overlooked by many - great, great multiplayer action!
One complaint - on the original version, the multiplayer match was set up as a best of three. This is no longer an option - matches are purely one game at a time. I found the best of three matches more fun because if two equally matched players compete, a single game can easily go either way. Sorta like basketball and reason they play best of 5 or 7 in a series.
Other than that, I love the game. The single player is OK, but the true genius of Dr. Mario is in the multiplayer! Give it a chance, it's one of the best puzzle games available.