I'm on my third playthrough of this game on Zealot (I had no problems playing on Easy and Normal). I am in the medical bay of the Ishimura and once I enter the room where you first encountered the regenerating necromorph in the first game I am attacked by two black slashers and two exploders. I deal with them no problem. However when I come to hack the door panel, I can only ever find one weak spot, as opposed to three when you normally hack them, and the door will not open.
Is this a glitch or is there a way around this? As I said I did not have this problem on my first two playthroughs