Tomb Raider has now been second in the charts for four weeks running.
FIFA 13 rounds out the top three, swapping positions with Defiance since last week. The MMO shooter with a TV show spin-off has to settle for fourth place in its second week on sale.
Luigi's Mansion 2 remains in fifth for its third week, followed up by the usual assortment of familiar titles: Call of Duty: Black Ops II in sixth, Assassin's Creed III in seventh, Gears of War: Judgment in eighth, Lego Batman 2: DC Super Heroes in ninth, and Far Cry 3 in 10th.
This week sees the release of DC Comics' fighter Injustice: Gods Among Us on the Xbox 360 and PlayStation 3. Will it be able to knock BioShock Infinite off the top spot next week?
The Top 20 UK chart for the week ending April 13:
1. BioShock Infinite
2. Tomb Raider
3. FIFA 13
5. Luigi's Mansion 2
6. Call of Duty: Black Ops II
7. Assassin's Creed III
8. Gears of War: Judgment
9. LEGO Batman 2: DC Super Heroes
10. Far Cry 3
11. Need for Speed: Most Wanted
12. Tiger Woods PGA Tour 14
13. LEGO Lord of the Rings
14. The Elder Scrolls V: Skyrim
15. Skylanders Giants
16. Halo 4
17. Sonic & All-Stars Racing Transformed
18. Just Dance 4
20. Sniper: Ghost Warrior 2