Nintendo has prohibited The Binding of Isaac from making its way to the 3DS eShop, according to tweets from the game's principal designer, Edmund McMillen.
"After a long internal debate, Nintendo has decided not to allow the Binding of Isaac on the 3DS," McMillen wrote.
As for why the game was rejected for release on the system, McMillen noted that the game's M-for-Mature rating was not to blame, but rather its "questionable religious content."
In The Binding of Isaac, players control a child who must escape the clutches of his mother, who is out to kill him after the voice of God commands a sacrifice. For more on the religious themes in The Binding of Isaac, check out the game's opening sequence, embedded below.
For more on the title, check out GameSpot's review of The Binding of Isaac.